A new type of DNA 'light-switch': a dual photochemical sensor and metalating agent for duplex and G-quadruplex DNA

Erin Wachter; Brock S. Howerton; Emily C. Hall; Sean Parkin; Edith C. Glazer

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A new type of DNA 'light-switch': a dual photochemical sensor and metalating agent for duplex and G-quadruplex DNA

机译：新型的DNA“光开关”：双光化学传感器和金属化剂，用于双链和G-四链DNA

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Ru(bpy)_2dppz, a well studied "light-switch" metal complex, transforms into a photochemical "light-switch" and DNA damaging agent by incorporating structural strain. This distorted compound is photo-reactive and ejects a ligand upon binding duplex and G-quadruplex DNA, producing a reactive metal center that metalates the DNA.

机译：Ru（bpy）_2dppz是一种经过充分研究的“光开关”金属配合物，通过引入结构应变而转变为光化学“光开关”和DNA破坏剂。这种扭曲的化合物具有光反应性，在结合双链体和G-四链体DNA时会弹出配体，从而产生使DNA金属化的反应性金属中心。

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《Chemical Communications》 |2014年第3期|311-313|共3页
作者
Erin Wachter; Brock S. Howerton; Emily C. Hall; Sean Parkin; Edith C. Glazer;
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Department of Chemistry, University of Kentucky, Lexington KY 40506, USA;

Department of Chemistry, University of Kentucky, Lexington KY 40506, USA;

Department of Chemistry, University of Kentucky, Lexington KY 40506, USA;

Department of Chemistry, University of Kentucky, Lexington KY 40506, USA;

Department of Chemistry, University of Kentucky, Lexington KY 40506, USA;

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入库时间 2022-08-17 13:14:50

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3. A pyrene dihydrodioxin with pyridinium "arms": A photochemically active DNA cleaving agent with unusual duplex stabilizing and electron trapping properties [J] . Khisamutdinov Emil F., Shamaev Alexei E., Karabaeva Kanykey E., Journal of Photochemistry and Photobiology, A. Chemistry . 2015,第Null期

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5. Interactions of small molecules with duplex DNA and lesion containing G-quadruplex DNA. [D] . Chitranshi, Priyanka. 2013

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A new type of DNA 'light-switch': a dual photochemical sensor and metalating agent for duplex and G-quadruplex DNA

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