Conversion of nitrite to nitric oxide at zinc via S-nitrosothiols

摘要

Nitrite is an important reservoir of nitric oxide activity in the plasma and celts. Using a biomimetic model, we demonstrate the conversion of zinc-bound nitrite in the tris(pyrazotyl)borate complex ~(IPr2)TpZn(NO_2) to the corresponding S-nitrosothiol RSNO and zinc thiolate ~(IPr2)TpZn-SR via reaction with thiols H-SR. Decomposition of the S-nitrosothiol formed releases nitric oxide gas.