Enantioselective desymmetrization of prochiral 1,3-dinitropropanes via organocatalytic allylic alkylationf

摘要

An enantioselective desymmetrization of prochiral 1,3-dinitropropanes has been developed which proceeds via enantiogroup differentiating organocatalytic allylic alkylation. Densely functionalized products with two vicinal stereocenters were obtained generally with good to excellent diastereoselectn/ity (up to >20:1 dr) and superb enantioselectivity (up to >99:1 er).