The notch-hes pathway in mammalian neural develop- ment

摘要

A wide variety of neurons and glial cells differentiate from common precursor cells in the developing nervous system. During this process, Notch-mediated cell-cell in- teraction is essential for maintenance of dividing cells and subsequent generation of cell type diversity. Activation of Notch inhibits cellular differentiation, and abnormality of The Notch pathway leads to premature neuronal differenti- Ation, the lack of some cell types, and severe defects of tis- Sue morpogenesis.