Suppression of angiotensin Ⅱstimualted responses in aortic vascular smooth muscle cells of experimental cir- rhotic rats

摘要

Functional responses to angiotensinⅡ(AT-Ⅱ)were determined in aortic vascular smooth muscle cells (VSMCs)from experimental cirrhotic rats. Our data showed that AT-Ⅱ-stimulated extracellular acidification rate(ECAR), which was measured reduced in the aortic VSMCs from the cirrhotic rats as compared to those from The control animals. The ability of AT-Ⅱto promote for- Mation of inositol phosphates, the second messenger pro- Duced by the activation of Gq-coupled receptors, was also Considerably suppressed in the cirrhotic VSMCs.