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首页> 外文期刊>Cancer Immunology, Immunotherapy >Immunotherapy with dendritic cells pulsed with tumor-derived gp96 against murine lung cancer is effective through immune response of CD8+ cytotoxic T lymphocytes and natural killer cells
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Immunotherapy with dendritic cells pulsed with tumor-derived gp96 against murine lung cancer is effective through immune response of CD8+ cytotoxic T lymphocytes and natural killer cells

机译：肿瘤来源的gp96脉冲树突状细胞对小鼠肺癌的免疫治疗通过CD8 +细胞毒性T淋巴细胞和自然杀伤细胞的免疫应答而有效

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摘要

Immunization with heat shock proteins, gp96, elicits specific protective immunity against parent tumors. However, it is marginally effective as a therapeutic tool against established tumors. In the present study, we evaluated the efficacy and mechanism of immunotherapy with bone marrow-derived dendritic cells (DCs) pulsed with tumor-derived gp96 against murine lung cancer.
机译：用热激蛋白gp96免疫可引起针对亲本肿瘤的特异性保护性免疫。但是，它作为针对已建立的肿瘤的治疗工具几乎是有效的。在本研究中，我们评估了用源自肿瘤的gp96脉冲刺激的骨髓源性树突状细胞（DC）对抗小鼠肺癌的免疫疗法的疗效和机制。

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  • 来源
    《Cancer Immunology, Immunotherapy》 |2008年第2期|165-174|共10页
  • 作者

    Naofumi Shinagawa; Koichi Yamazaki; Yasuaki Tamura; Akihito Imai; Eiki Kikuchi; Hiroshi Yokouchi; Fumihiro Hommura; Satoshi Oizumi; Masaharu Nishimura;

  • 作者单位

    First Department of Medicine Hokkaido University School of Medicine North 15 West 7 Kita-ku Sapporo 060-8638 Japan;

    First Department of Medicine Hokkaido University School of Medicine North 15 West 7 Kita-ku Sapporo 060-8638 Japan;

    Department of Pathology Sapporo Medical University School of Medicine Sapporo Japan;

    Department of Pathology Sapporo Medical University School of Medicine Sapporo Japan;

    First Department of Medicine Hokkaido University School of Medicine North 15 West 7 Kita-ku Sapporo 060-8638 Japan;

    First Department of Medicine Hokkaido University School of Medicine North 15 West 7 Kita-ku Sapporo 060-8638 Japan;

    First Department of Medicine Hokkaido University School of Medicine North 15 West 7 Kita-ku Sapporo 060-8638 Japan;

    First Department of Medicine Hokkaido University School of Medicine North 15 West 7 Kita-ku Sapporo 060-8638 Japan;

    First Department of Medicine Hokkaido University School of Medicine North 15 West 7 Kita-ku Sapporo 060-8638 Japan;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Heat shock protein; gp96; Dendritic cell; Immunotherapy; Lung cancer;

    机译：热休克蛋白gp96树突状细胞免疫治疗肺癌;
  • 入库时间 2022-08-18 01:40:14

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