Heat shock protein 90 inhibition abrogates hepatocellular cancer growth through cdc2-mediated G₂/M cell cycle arrest and apoptosis

摘要

Purpose 17-(demethoxy), 17-allylamino geldanamycin (17-AAG) suppresses growth in some cancers by inhibiting Heat shock protein 90 (Hsp90). We examined the effects of 17-AAG-mediated Hsp90 inhibition on human hepatocellular carcinoma (HCC) growth in vitro and in vivo.