Phase 1 study of ganitumab (AMG 479), a fully human monoclonal antibody against the insulin-like growth factor receptor type I (IGF1R), in Japanese patients with advanced solid tumors

Haruyasu Murakami; Toshihiko Doi; Nobuyuki Yamamoto; Junichiro Watanabe; Narikazu Boku; Nozomu Fuse; Takayuki Yoshino; Atsushi Ohtsu; Satoru Otani; Kazuhiro Shibayama

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Phase 1 study of ganitumab (AMG 479), a fully human monoclonal antibody against the insulin-like growth factor receptor type I (IGF1R), in Japanese patients with advanced solid tumors

机译：ganitumab（AMG 479）的1期研究在日本患有晚期实体瘤的患者中，它是针对人胰岛素样生长因子I型（IGF1R）的完全人类单克隆抗体

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Purpose This study was to investigate the safety and tolerability of ganitumab in Japanese patients with advanced solid tumors.

机译：目的本研究旨在探讨加尼他单抗在日本晚期实体瘤患者中的安全性和耐受性。

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《Cancer Chemotherapy and Pharmacology 》 |2012年第3期| p.407-414| 共8页
作者
Haruyasu Murakami; Toshihiko Doi; Nobuyuki Yamamoto; Junichiro Watanabe; Narikazu Boku; Nozomu Fuse; Takayuki Yoshino; Atsushi Ohtsu; Satoru Otani; Kazuhiro Shibayama;
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1. Phase 1 study of ganitumab (AMG 479), a fully human monoclonal antibody against the insulin-like growth factor receptor type i (IGF1R), in Japanese patients with advanced solid tumors [J] . MurakamiH., DoiT., YamamotoN., Cancer chemotherapy and pharmacology. . 2012 ,第3期

机译：ganitumab（AMG 479）的1期研究在日本患有晚期实体瘤的患者中，它是一种针对人胰岛素样生长因子I型（IGF1R）的完全人类单克隆抗体
2. Safety, tolerability, pharmacokinetics and antitumor activity of ganitumab, an investigational fully human monoclonal antibody to insulin-like growth factor type 1 receptor, combined with gemcitabine as first-line therapy in patients with metastatic pancreatic cancer: a phase 1b study. [J] . OkusakaT., IkedaM., FukutomiA., Japanese journal of clinical oncology. . 2014 ,第5期

机译：Ganitumab的安全性，耐受性，药代动力学和抗肿瘤活性，一种针对胰岛素样生长因子1型受体的研究性全人类单克隆抗体，结合吉西他滨作为转移性胰腺癌患者的一线治疗药物：1b期研究。
3. Phase I study of humanized monoclonal antibody AVE1642 directed against the type 1 insulin-like growth factor receptor (IGF-1R), administered in combination with anticancer therapies to patients with advanced solid tumors [J] . MacaulayV.M., MiddletonM.R., ProtheroeA.S., Annals of oncology: official journal of the European Society for Medical Oncology . 2013 ,第3期

机译：针对1型胰岛素样生长因子受体（IGF-1R）的人源化单克隆抗体AVE1642的I期研究，与抗癌疗法联合用于晚期实体瘤患者
4. HER1 THERAPEUTIC CANCER VACCINE: AN ACTIVE IMMUNOTHERAPY TREATMENT FOR PATIENTS WITH TUMORS EXPRESSING THE RECEPTOR OF EPIDERMAL GROWTH FACTOR (EGF-R) [C] . Eduardo Suarez, Belinda Sanchez, Zaima Mazorra, Conference on vaccine technology VI . 2018

机译：HER1癌症治疗疫苗：一种针对表皮生长因子（EGF-R）受体的肿瘤的主动免疫疗法
5. The role of the type I insulin-like growth factor receptor in lung tumorigenesis [D] . Siwicky, Megan Danielle. 2009

机译：I型胰岛素样生长因子受体在肺肿瘤发生中的作用
6. Phase 1 study of ganitumab (AMG 479) a fully human monoclonal antibody against the insulin-like growth factor receptor type I (IGF1R) in Japanese patients with advanced solid tumors [O] . Haruyasu Murakami, Toshihiko Doi, Nobuyuki Yamamoto, -1

机译：ganitumab（AMG 479）的1期研究在日本患有晚期实体瘤的患者中它是针对人胰岛素样生长因子I型（IGF1R）的完全人类单克隆抗体
7. Phase 1 study of ganitumab (AMG 479), a fully human monoclonal antibody against the insulin-like growth factor receptor type I (IGF1R), in Japanese patients with advanced solid tumors [O] . Haruyasu Murakami, Toshihiko Doi, Nobuyuki Yamamoto, 2012

机译：ganitumab（AMG 479）的1期研究在日本患有晚期实体瘤的患者中，它是针对I型胰岛素样生长因子受体（IGF1R）的完全人类单克隆抗体
8. Type-I Insulin-Like Growth Factor Receptor (IGF1R)-Estrogen Receptor (ER) Crosstalk Contributes to Antiestrogen Therapy Resistance in Breast Cancer Cells. [R] . Fagan, D. 2013

机译：I型胰岛素样生长因子受体（IGF1R） - 雌激素受体（ER）串扰有助于乳腺癌细胞中的抗雌激素治疗抗性。

Phase 1 study of ganitumab (AMG 479), a fully human monoclonal antibody against the insulin-like growth factor receptor type I (IGF1R), in Japanese patients with advanced solid tumors

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