The effects of hematological parameters and tumor-infiltrating lymphocytes on prognosis in patients with gastric cancer

摘要

BACKGROUND: It is well known that tumor-infiltrating lymphocytes (TIL) and, to a lesser extent, peripheral hematologicnparameters from patients with cancer have to effect on prognosis. The aim of this study was to evaluate the effect of hematologicnparameters and TIL on prognosis of patients with gastric cancer.nMETHODS: 236 patients who had diagnosed as gastric adenocarcinoma. All hematologic parameters were noted at the time ofndiagnosis. The number of lymphocyte aggregates as well as the number of lymphocytes within these agregat was counted.Thenprognostic significance and correlations of high neutrophil-lymphocyte ratio (NLR) together with TIL, was evaluated by multivariednanalysis.nRESULTS: The cut-off values of NLR and derived NLR (dNLR) were 3.8 and 2. The NLR was independently associated withnsurvival (P <0.001). dNLR was not independently associated with overall survival. No significant advantages for overall survivalnwere found for the high TIL (p: 0.372). It was not determined correlation between TIL – NLR and TIL-lymphoid aggregatendensity (respectivly, P: 0.104; P: 0.246).nCONCLUSIONS: The results suggest that the elevated NLR predicts poor overall survival following at the time diagnosis for allnstage gastric cancer. dNLR was not independently associated with overall survival. There is insufficient evidence to the assesmentnof TIL by a nonspesific method. Therefore further studies is required, to confirm our hypothesis in larger patient cohorts.