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Assessment of hazards posed to fluid-borne cells in airlift reactors

机译:评估空运反应堆中的流体传播细胞的危害

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In sparged reactors, interfacial phenomena can produce very energetic liquid-phase motions; the important interfacial events may include bubble formation, bubble breakage and coalescence, and bubble disengagement. The latter has gen- erally been singled out as a leading cause of cellular damage and death in the large-scale culture of mammalian cells. In the present work, the danger to cells posed by disengagement phenomena in airlift reactors is quantified through the combination of three separate factors: 1)the number of exposures per hour of operation; 2)the mean residence time (per exposure) in the region of the disengagement disturbances; and 3) the disturbance energy contained in the appropriate range of frequencies.
机译:在喷射反应器中,界面现象会产生非常活跃的液相运动。重要的界面事件可能包括气泡形成,气泡破裂和聚结以及气泡脱离。后者通常已被选为哺乳动物细胞大规模培养中细胞损伤和死亡的主要原因。在目前的工作中,空运反应堆中分离现象对细胞的危害通过三个独立的因素进行量化:1)每小时运行的暴露次数; 2)在脱离干扰区域内的平均停留时间(每次曝光); 3)包含在适当频率范围内的干扰能量。

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