Adaptive multirate estimation and control of nutrient levels in a fed-batch fermentation using off-line and on-line measurements

摘要

A multirate adaptive estimation algorithm developed earlier (Gudi et al., 1995) is extended to perform estimation of nutrient levels using frequent on-line measurements of the carbon dioxide evolution rate(CER) and off-line, infrequent and delayed measurements of the biomass and substrate concentrations. It has been shown that the algorithm can be designed to track changing substrate yield coefficients as well. The estimation algorithm has been verified using simu- lations and industrial data from a fed-batch fermentation involving a Streptomyces specie.