Kinetic and Thermodynamic Principles Determining the Structural Design of ATP-producing Systems

摘要

It is theoretically analysed whether the structural design of ATP-producing path- ways, in particular the design of glycolysis, may be explained by optimization principles. On the basis of kinetic and thermodynamic principles conclusions are derived concerning the stoichiometry of these pathways in states of high ATP production rates. One of the extensions to previous investigations is that the concentrations of the adenine nucleotides are taken into account as variable quan- tities.