Modeling the T-cell Dynamics and Pathogenesis of HTLV-I Infection

摘要

Human T-cell lymphotropic virus type I (HTLV-I) infection in humans causes a chronic infection of CD4~+ T cells, and is associated with various disease outcomes, among them with the development of adult T-cell leukemia (ATL). The T-cell dy- namics after HTLV-I infection can be described in a mathematical model with cou- pled differential equations. The infection process is modeled assuming cell-to-cell infection of CD4~+ T cells. The model allows for CD4~+ T cell subsets of sus- ceptible, latently infected and actively infected cells as well as for leukemia cells.