A Model of Cell Cycle Behavior Dominated by Kinetics of a pathway Stimulated by Growth Factors

摘要

A modified version of a previously developed mathematical model [Obeyesekere et al., Cell prolif. (1997)] of the G1-phase of the cell cycle is presented. This model describes the regulation of the G1-phase that includes the interactions of the nuclear proteins, RB, cyclin E, cyclin D, cdk2, cdk4 and E2F. The effects of the growth factors on cyclin D synthesis under saturated or unsaturated growth factor conditions are investigated based on this model. The solutions to this model (a system of nonlinear ordinary differential equations) are discussed with respect to existing experiments.