The case against aggressive treatment of type 2 diabetes: critique of the UK prospective diabetes study

摘要

The United Kingdom prospective diabetes study (UKPDS) is seriously flawed, and its results do not justify a policy of aggressive treatment of type 2 diabetes. The study's flaws arise from changes that were made in the trial as it progressed. I searched Medline (Ovid's CD version) from 1976 to March 2000, using various combinations of the keywords "UKPDS" and "prospective diabetes study" and the names of the principal authors of the study's reports. I reviewed the resulting articles for any description of the design of the UKPDS. I reviewed reference lists for other references.