Trigeminal nerve ganglion stimulation-Induced neurovascular reflexes in the anaesthetized cat: Role of endothelin_B receptors in carotid vasodilatation

摘要

1. The effects of intravenous administration of endothelin (ET) receptor antagonists SB-209670 (0.001 - 10.0 mg kg~-1), SB - 217242, SB - 234551 (0.01-10.0 mg kg~-1) and BQ - 788 (0.001- 1.0 kg~-1) were investigated on trigeminal nerve ganglion stimulation-induced neurovascular reflexes in the carotid vasculature of the anaesthetized cat. Comparisons were made with sumatriptan (0.003-3.0 mg kg~-1) and α-CGRP_8-37 (0.001 - 0.1 mg kg~-1).