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β-Adrenoceptor-mediated effects in rat cultured thymic epithelial cells

机译:β-肾上腺素受体介导的大鼠胸腺上皮细胞培养作用

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摘要

Incubation with isoprenaline or the adenylate cyclase activator forskolin decreased basal and serum- stimulated proliferation of thymic epithelial cells. However, adrenergic stimulation of thymic epithelial cells did not induce interleukin 1 production. Since thymic epithelial cells create a microenvironment which influences the maturation and differentiation of thymocytes to T-lymphocytes, their observed capacity to respond to catecholamines provides novel evidence for the suggestion that darenergic stimulation may interfere with the regulation of immune functions.
机译:与异丙肾上腺素或腺苷酸环化酶激活剂福司可林一起孵育可降低基础和血清刺激的胸腺上皮细胞的增殖。然而,胸腺上皮细胞的肾上腺素刺激不能诱导白介素1的产生。由于胸腺上皮细胞产生了影响胸腺细胞向T淋巴细胞成熟和分化的微环境,因此观察到的它们对儿茶酚胺的反应能力为暗示达能能刺激可能干扰免疫功能的调节提供了新的证据。

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