Inhibitory effect of nitrovasodilators and cyclic GMP on ET-1- activated Ca~2+ -permeable nonselective cation channel in rat aortic smooth muscle cells

摘要

These results taken together indicate that NO through a cyclic GMP signaling pathway inhibits ET- 1 -activated Ca~2+ -permeable nonselective cation channels, thereby suppressing the sustained increase in [Ca~2+]_ⅰ. Thus, the present study indicates that this Ca~2+ -permeable nonselective cation channel is an important target for nitrovasodilators