Stimulation of cyclic AMP-dependent protein kinase in rat atria by (-)-CGP 12177 through an atypical β-adrenoceptor

摘要

Mammalian hearts possess an atypical β-adrenoceptor (non-β_1, non-β_2, non-β_3) through which (-)-4-(3- t-butylamino-2-hydroxypropoxy) benzimidazol-2-one ((-)-CGP 12177) causes cardiostimulant effects. Here we showed that (-)-CGP 12177 increased the activity of adenosine 3':5'-cyclic monophosphate (cyclic AMP) -dependent protein kinase in the presence of 200 nM (-)-propranolol in rat atria at a concentration (10 μM) that elicits maximum positive chronotropic and inotropic effects .