[Ca~2+]_ⅰ oscillations induced by muscarinic stimulation in airway smooth muscle cells: receptor subtypes and correlation with the mechanical activity

摘要

In conclusion, the present study indicates that muscarinic stimulation of rat isolated tracheal smooth muscle cells induces [Ca~2+]_ⅰ oscillations. The occurrence of these oscillations depends on the graded amplitude of the first [Ca~2+]_ⅰ rise and their frequency may play a role in the amplitude of the mechanical activity in response to muscarinic cholinoceptor activation. Both the [Ca~2+]_ⅰ and the contractile responses are primarily dependent on ctivation of the M_3 receptor subtype.