首页> 外文期刊>British Journal of Pharmacology >Comparison of the reversed passive Arthus and local Shwartzman reactions of rabbit skin: effect of the long-acting PAF antagonist UK-74,505
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Comparison of the reversed passive Arthus and local Shwartzman reactions of rabbit skin: effect of the long-acting PAF antagonist UK-74,505

机译:兔皮肤逆向被动性Arthus反应与局部Shwartzman反应的比较:长效PAF拮抗剂UK-74,505的作用

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摘要

The results demonstrate that PAF is an important mediator of oedema formation, but not neutrophil accumulation, in the immune-complex mediated RPA reaction in rabbit skin. PAF also appears to be required for platelet, but not neutrophil, accumulation in response to locally injected LPS. Our studies do not suggest a role for PAF in the LPS-mediated LSR.
机译:结果表明,在免疫复合物介导的兔皮肤RPA反应中,PAF是水肿形成的重要介质,但不是中性粒细胞积累的重要介质。血小板(而非嗜中性粒细胞)对局部注射LPS的反应似乎也需要PAF。我们的研究没有表明PAF在LPS介导的LSR中的作用。

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