The relative potencies of dendrotoxins as blockers of the cloned voltage-gated K~+ channel, mKv1.1 (MK-1), when stably expressed in Chinese hamster ovary cells

David G.Owen; Adam Hall; Gary Stephens

首页> 外文期刊>British Journal of Pharmacology >The relative potencies of dendrotoxins as blockers of the cloned voltage-gated K~+ channel, mKv1.1 (MK-1), when stably expressed in Chinese hamster ovary cells

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The relative potencies of dendrotoxins as blockers of the cloned voltage-gated K~+ channel, mKv1.1 (MK-1), when stably expressed in Chinese hamster ovary cells

机译：当在中国仓鼠卵巢细胞中稳定表达时，树突毒素作为克隆的电压门控的K〜+通道mKv1.1（MK-1）的阻断剂的相对效能

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摘要

A wide range of activity was observed even between toxins with an extremely high degree of sequence homology. Toxin K, in particular was an exquisitely potent blocker of the mKvl.1 channel, having an EC_50 of 30 pM compared with 1.8nM for δ-Dtx in spite of 95/100 sequence identity.

机译：即使在具有极高序列同源性的毒素之间也观察到了广泛的活性。毒素K特别是mKv1.1通道的强效阻断剂，尽管具有95/100序列同一性，但δ-Dtx的EC_50为30 pM，而δ-Dtx的EC_50为1.8nM。

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《British Journal of Pharmacology》 |1997年第6期|p.1029-1034|共6页
作者
David G.Owen; Adam Hall; Gary Stephens;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类药理学;
关键词
Dendrotoxins; voltage-gated K~+ channel; Chinese hamster ovary cell;

机译：树突毒素;电压门控K〜+通道;中国仓鼠卵巢细胞;
入库时间 2022-08-18 00:42:52

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6. The relative potencies of dendrotoxins as blockers of the cloned voltage-gated K+ channel mKv1.1 (MK-1) when stably expressed in Chinese hamster ovary cells [O] . David G Owen, Adam Hall, Gary Stephens, 1997

机译：当在中国仓鼠卵巢细胞中稳定表达时树突毒素作为克隆的电压门控K +通道mKv1.1（MK-1）的阻断剂的相对效力
7. The relative potencies of dendrotoxins as blockers of the cloned voltage-gated K+ channel, mKv1.1 (MK-1), when stably expressed in Chinese hamster ovary cells [O] . Owen, David G, Hall, Adam, Stephens, Gary, 1997

机译：当在中国仓鼠卵巢细胞中稳定表达时，树突毒素作为克隆的电压门控K +通道mKv1.1（MK-1）的阻断剂的相对效力
8. Cloning and Functional Expression of Dendrotoxin K from Black Mamba, a K+ ChannelBlocker [R] . Smith, L. A., Lafaye, P. J., LaPenotiere, H. F., 1993

机译：K + ChannelBlocker黑曼巴中Dendrotoxin K的克隆和功能表达

The relative potencies of dendrotoxins as blockers of the cloned voltage-gated K~+ channel, mKv1.1 (MK-1), when stably expressed in Chinese hamster ovary cells

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