Mechanism of actions of sumatriptan on coronary flow before and after endothelial dysfunction in guinea-pig isolated heart

摘要

In man, sumatriptan and 5-HT may both be capable of causing pathogenic coronary vasoconstriction. The implications of the present data are that the scope for this may depend greatly on (ⅰ) the extent of underlying endothelial dysfunction, (ⅱ) the extent of endothelial 5-HT_2 receptor- mediated release of vasodilator autacoids (which include NO) and (ⅲ) the extent of smooth muscle 5-TH_1D receptor-mediated vasoconstriction.