Enhancement of the response to purinergic agonists in P2Y_1 transfected 1321N1 cells by antagonists suramin and PPADS

摘要

however, when 2MeSATP was added in the absence of a change of medium and with no antagonist present, there was a several fold increase in [~3H]-InsP_x accumulation. These results show that a release of endogenous agonist activity (possibly ATP/ADP)from the P2Y_1 expressing cells can create conditions in which a response to an agonist such as 2MeSATP can only be seen in the presence of a competitive antagonist.