The effects of bradykinin on K~+ currents in NG108-15 cells treated with U73122, a phospholipase C inhibitor, or neomycin

摘要

The four main conclusions drawn from the results are: (a) U73122 suppresses bradykinin-induced PLC activation and I_K(Ca), but not I_M inhibition. (b) This indicates that the transient outward current I_K(Ca), but not the decrease of I_M in response to bradykinin, is mediated by PLC. (c)U73122 itself inhibits I_M and mobilizes Ca~2+ from intracellular stores. (d) Externally applied neomycin is not an effective inhibitor of PLC-mediated signaling pathways in NG108-15 cells.