The effect of pretreatment with a δ_2-opioid receptor antisense oligodeoxynucleotide on the recovery from acute antinociceptive tolerance to δ_2-opioid receptor agonist in the mouse spinal cord

摘要

Based on these findings, it is concluded that a single stimulation of spinal cord δ_2-opioid receptors by intrathecally-administered [D-Ala~2] deltorphin Ⅱ induces a long-lasting desensitization of δ_2-opioid receptors to [D-Ala~2] deltorphin Ⅱ. Recovery from δ_2-opioid receptor-mediated antionciceptive tolerance apparently depends on replenishment by mewly synthesized δ_2-opioid receptor protein rather than immediate reversal of δ_2-opioid receptors.