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Increased response to big endothelin-1 in atherosclerotic human coronary artery: functional evidence for up-regulation of endothelin-converting enzyme activity in disease

机译:对动脉粥样硬化性人类冠状动脉中大内皮素-1的反应增加:疾病中内皮素转化酶活性上调的功能证据

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摘要

Overproduction of the potent vasoconstrictor peptide endothelin-1 (ET-1) is implicated in the pathogenesis of coronary artery disease. In endothelium-denuded human coronary arteries the response to big ET-1 was significantly enhanced in atherosclerotic arteries(coronary artery disease, CAD; n=7) with an EC_50 value of 96 nM(57-161 nM, 95/100 C.I.) compared to 274 nM(205-365 nM) in non-diseased arteries (dilated cardiomyopathy, DCM; n =10) (Mann-Whitney U-test, P<0.05). higher levels of immunoreactive endothelin(ET) could be detected by radioimmunoassay in bathing medium taken from CAD arteries than from DCM arteries(2.8 ±0.5 nM. N =5 vs 1.1±0.2 nM, n =7)(student's two-tailed t-test, P<0.05).
机译:有效的血管收缩肽内皮素-1(ET-1)的过量生产与冠状动脉疾病的发病机理有关。在内皮剥夺的人冠状动脉中,对大ET-1的反应在动脉粥样硬化性动脉(冠状动脉疾病,CAD; n = 7)中显着增强,EC_50值为96 nM(57-161 nM,95/100 CI)至非病变动脉中的274 nM(205-365 nM)(扩张型心肌病,DCM; n = 10)(Mann-Whitney U检验,P <0.05)。通过放射免疫分析,在取自CAD动脉的沐浴介质中检测到的免疫反应性内皮素(ET)的水平高于DCM动脉(2.8±0.5 nM。N = 5 vs 1.1±0.2 nM,n = 7)(学生的两尾t-测试,P <0.05)。

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