Actions of general anaesthetics and arachidonic acid pathway inhibitors on K~+ currents activated by volatile anaesthetics and FMRFamide in molluscan neurones

摘要

K~+ currents activated by volatile general anaesthetics(I_K(An)) and by the neuropeptide FMRFamide (I_K(FMRFa) were studied under voltage clapme in isolated identified neurones from the pond snail Lymnaea stagnalis. I_K(An) was activated by all the volatile anaesthetics studied. The maximal responses varied from agent To agent, with halothane ≈sevoflurane > isoflurane>enflurane ≈chloroform. I_K(An) was inhibited rather than activated by the n-alcohols from hexanol to dodecanol and by the 6- And 8-carbon cycloalcohols. The n-alcohols exhibited a cutoff effect, with dodecanol being unable to Half-inhibit I-K(An).