首页> 外文期刊>British Journal of Pharmacology >Influence of aminoguanidine on parameters of liver injury and regeneration induced in rats by a necrogenic dose of thioacetamide
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Influence of aminoguanidine on parameters of liver injury and regeneration induced in rats by a necrogenic dose of thioacetamide

机译:氨基胍对坏死剂量硫代乙酰胺诱导的大鼠肝损伤和再生参数的影响

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摘要

When aminoguanidine, a nucleophilic hydrazine compound, was administered to rats(50 mg kg~-1 body wt)30 min before a necrogenic dose of thioacetamide(500 mg kg~-1 body wt), significant changes related to liver injury and hepatocellular regeneration were observed. The extent of necrosis was noticeably less pronounced, as detected by the peak of serum aspartate Aminotransferase activity. Depletion of hepatic glutathione(GSH) and the increase in malondialdehyde Concentration as markers of oxidative stress, produced by thioacetamide metabolism, were significantly Diminished. However, the activity of microsomal FAD monooxygenase, the system responsible for Thioacetamide oxidation, did not show significant alterations. Altioxidant enzyme systems involved in The glutathione redox cycle, such as glutathione reductase and glutathione peroxidase activities slightly Decreased following aminoguanidine pretreatment.
机译:当致死剂量的硫代乙酰胺(500 mg kg〜-1体重)之前30分钟,将亲核肼化合物氨基胍(50 mg kg〜-1体重)给予大鼠,与肝脏损伤和肝细胞再生有关被观察。如血清天冬氨酸氨基转移酶活性的峰值所检测,坏死的程度不那么明显。硫代乙酰胺代谢产生的肝谷胱甘肽(GSH)耗竭和丙二醛浓度升高(氧化应激的标志物)显着降低。但是,微粒体FAD单加氧酶(负责硫代乙酰胺氧化的系统)的活性未显示出明显的变化。谷胱甘肽氧化还原循环中涉及的Altioxidant酶系统,例如谷胱甘肽还原酶和谷胱甘肽过氧化物酶活性在氨基胍预处理后略有下降。

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