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Differential effect of propofol on sympathetic neurotransmission in isolated human omental arteries and veins

机译:异丙酚对人网膜动脉和静脉中交感神经传递的差异作用

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The present study was undertaken to elucidata the effect of propofol on sympathetic neurotransmission in isolated human omental vessels. Segments of both arteries and veins were exposed to 0, 10~-7, 10~-6, 10~-5 or 10~-4 M propofol, and Studied in vitro to determine effects on: (i) isometric tension after electrical field stimulation(EFS) or After exogenous administration of noradrenaline(NA); (ii) EFS-stimulated release of [~3H]-NA from Vessel segments preincubated with [~3H]-NA; (iii) uptake of [~3H]-NA. Propofol at 10~-6 M enhanced EFS-induced contraction in artery segments, 10~-7 and 10~-5 M had no Effect, and 10~_4 M propofol depressed EFS-induced contraction in both artery and vein segments.
机译:进行本研究以阐明异丙酚对分离的人网膜血管中交感神经传递的影响。将动脉和静脉段暴露于0、10〜-7、10〜-6、10〜-5或10〜-4 M的异丙酚中,并进行体外研究以确定对以下方面的影响:(i)电场后的等轴测张力刺激(EFS)或去甲肾上腺素(NA)外用后; (ii)从EFS刺激的[〜3H] -NA预培养的血管片段中释放[〜3H] -NA; (iii)吸收[〜3H] -NA。异丙酚在10〜-6 M时可增强EFS引起的动脉节段收缩,而10〜-7和10〜-5 M则无作用,而10〜_4 M异丙酚可抑制EFS引起的动脉和静脉节段收缩。

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