The transport of the anti-HIV drug, 2',3'-didehydro-3'- deoxythymidine (D4T), across the blood-brain and blood-cerebrospinal fluid barriers

摘要

The brain is a site of infection, viral replication and sanctuary for HIV-1. The treatment of HIV-1 infection therefore requires that an effective agent be delivered to the brain. 2',3'-Didehydro-3'- deoxythymidine(D4T)is a nucleoside analogue which has been shown to have beneficial clinical effects in the treatment of HIV infection. However, although D4T has been detected in human CSF, the ability of this drug to cross both the blood-brain and blood-cerebrospinal fluid(CSF) barriers and gain entrance into the brain tissue is not known. This study examined the CNS entry of D4T by means of the bilateral vascular brain perfusion Technique in the anaesthetized guinea-pig.