首页> 外文期刊>British Journal of Pharmacology >Inhibitors of the activity of poly(ADP-ribose) synthetase reduce the cell death caused by hydrogen peroxide in human cardiac myoblasts
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Inhibitors of the activity of poly(ADP-ribose) synthetase reduce the cell death caused by hydrogen peroxide in human cardiac myoblasts

机译:聚(ADP-核糖)合成酶活性的抑制剂可减少人心肌成肌细胞中过氧化氢引起的细胞死亡

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摘要

Poly (ADP-ribose) synthetase (PARS) is a nuclear enzyme activated by strand breaks in DNA which are caused by reactive oxygen species (POS). Inhibitors of PARS activity reduce the degree of reperfusion injury of the heart in vivo and in vitro. Here we investigated the role of RARS in the cell death of human cardiac myoblasts caused by hydrogen peroxide. Exposure of human cardiac myoblasts to hydrogen peroxide caused a time- and concentration- Dependent reduction in mitochondrial respiration (cell injury), an increase in cell death (LDH release), as Well as an increase in PARS activity.
机译:聚(ADP-核糖)合成酶(PARS)是一种由DNA链断裂激活的核酶,该断裂是由活性氧(POS)引起的。 PARS活性抑制剂可在体内和体外降低心脏的再灌注损伤程度。在这里,我们研究了RARS在过氧化氢引起的人类心肌成肌细胞死亡中的作用。人类心脏成肌细胞暴露于过氧化氢会导致线粒体呼吸(细胞损伤)的时间和浓度依赖性降低,细胞死亡(LDH释放)增加以及PARS活性增加。

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