Calcium influx inhibition by steroids and analogs in C2C12 skeletal muscle cells

摘要

Glucocorticoids, namely α-methylprednisolone(PDN) and deflazacort, are the only drugs reported to have a beneficial effect on the degenerative course of Duchenne muscular dystrophy(DMD). Increased cytosolic calcium concentrations ([Ca~2+]c) have been implicated as one of the pathological Events responsible for the degeneration of dystrophic skeletal muscles. In previous studies, we have Demonstrated that PDN treatment of both normal and dystrophic murine skeletal muscle cells was Able to normalize elevated [Ca~2+]c and improved myogenesis. Here we have investigated the Mechanism underlying the effects of glucocorticoids on cellular Ca~2+ influx into C2C12 skeletal muscle Cells.