Increased susceptibility of gastric mucosa to ulcerogenic stimulation in diabetic rats-role of capsaincin-sensitive sensory neurons

摘要

We examined the gastric mucosal blood flow (GMBF) and ulcerogenic responses following barrier disruption induced by sodium taurocholate(TC) in diabetic rats and investigated the role of capsaicin- sensitive sensory neurons in these responses. Animals were injected streptozotocin (STZ: 70 mg kg~-1, i.p.) and used after 5, 10 and 15 weeks of Diabetes were glucose levels of >350 mg dl~-1. The stomach was mounted on an ex-vivo chamber Under urethane anaesthesia and exposed to 20 mM TC plus 50 mM HCl for 30 min in the presence of Omeprazole. Gastric transmucosal potential difference(PD), GMBF, and luminal acid loss (H~+ back- Diffusion) were measured before and after exposure to 20 mM TC, and the mucosa was examined for Lesions 90 min after TC treatment.