The intravenous administration of tumor necrosis factor alpha, interleukin 8 and macrophage-derived neutrophil chemotactic factor inhibits neutrophil migration by stimulating nitric oxide production

摘要

The i.v. administration of tumor necrosis factor-α(TNF-α), interleukin-8(IL-8) and the recently described macrophage-derived neutrophil chemotactic factor (MNCF) inhibits the recruitment of neutrophils to the inflammatory site. Pretreatment of mice with the NO synthase antagonist, N~G-monomethyl-L-arginine(L-NMMA, 15- 60 mg kg~-1), but not the inactive enantiomer D-NMMA(30 mg kg~-1), prevented in a dose-dependent manner the TNF-α, IL-8 and MNCF-mediated inhibition of neutrophil migration into thioglycollate- challenged peritoneal cavities.