Protective effects of a superoxide dismutase mimetic and peroxynitrite decomposition catalysts in endotoxin-induced intestinal damage

摘要

1. The relative contributions of superoxide anion (O_2~-) and peroxynitrite (PN) were evaluated in the pathogenesis of intestinal microvascular damage caused by the intravenous injection of E. coli lipopolysaccharide (LPS) in rats. The superoxide dismutase mimetic (SODm) SC-55858 and the active peroxynitrite decomposition catalysts 5, 10, 15- 20-tetrakis (2, 4, 6-trimethyl-3, 5-disulphonatophe- nyl)-porphyrinato iron (III) and 5, 10, 15, 20-tetrakis (N-methyl-4'-Pyridyl)-porphyrinato iron (III) (FeTMPS, FeTMPyP respectively) were used toassess the roles of O_2~- and PN respectivley.