Cytosolic Ca~2+ movements of endothelial cells exposed to reactive oxygen intermediates: role of hydroxyl radical-mediated redox alteration of cell-membrane Ca~2+ channels

摘要

1. The mode of action of reactive oxygen intermediates in cysosolic a~2+ movements of cultured porcine aortic endothelial cells exposed to xanthine/xanthine oxidase (X/XO) was investigated. 2. Cytosolic Ca~2+ movements provoked by X/XO consisted of an initial CA~2+ release from thapsigargin-sensitive intracellular Ca~2+ stores and a sustained Ca~2+ influxthrough cell-membrane Ca~2+ channels.