Effects of propafenone on K currents in human atrial myocytes

摘要

1. The class Ic anti-arrhythmic agent, flecainide is known to inhibit the transient outward K current (Ito) selectively in human atrium. We studied the effects of propafenone, another class IC anti- arrhythmic agent. On K currents in human atrial myocytes using a whole-cell voltage-clamp method. 2. propafenon inhibited both Ito and the sustained or ultra-rapid delayed rectifier K current (Isus or Ikur) evoked by depolarization pulses.