Role of potassium channels in the antinociception induced by agonists of α_2-adrenoceptors

摘要

1 the effect of the administration of pertussis toxin (PTX) as well as modulators of different subtypes of K~+ channels on the antinociception induced by clonidine and guanabenz was evaluated in the mouse hot plate test. 2. Preteatment with pertussis toxin (0.25 μg per mouse i. c. v.) 7 days before the hot-plate test, prevented the antinociception induced by both clonidine (0.08-0.2 mg kg~-1, s. c.) and guanabenz (0.1-0.5 mg kg`-1, s. c.).