Effects of vitamin C and of a cell permeable superoxide dismutase mimetic on acute lipoprotein induced endothelial dysfunction in rabbit aortic rings

摘要

1. Low denisty lipoprotein (LDL) inhibits endothelium-dependent relaxation. The mechanism is uncertain, but increased production of superoxide anion O_2 with inactivation of endothelium-derivd No and formation of toxic free radical species have been implicated. We investigated effects of the cell Permeable superoxide dismutase mimetic manganese (III) tetrakis (1-methyl-4-pyridyl) porphyrin (Mn TMPyP), the free radical scavenger vitamin C and arginine (which may reduce O_-formation) on acute LDL-induced endothelial dysfunction in rabbit aortic rings, using LDL prepared by ultracentrifugation of plasma from healthy men and aortic rings form New Zealand white rabbits.