Suppression of nitric oxide synthase and the down-regulation of the activation of NFkB in macrophages by resveratrol

摘要

1. Resveratrol, naringenin and naringin are naturally occurring flavonoids in grapes and grapefruits. The anit-inflammatory effects of these flavonoids have been well documented, but the mechanism is poorly characterized. High concentration of NO are produced by inducible NO synthase (iNOS) in inflammation, and the prevention of the expression of iNOS may be an important anti-inflammatory mechanism. In this study, the effects of these flavonoids on the induction of NO synthase (NOS) in RAW 264.7 cells activated with bacterial lipopolysaccharide (LPS, 50 NG ML`-1) were investigated.