Functional and molecular biological evidence for a possible β _3-adrenoceptor in the human detrusor muscle

摘要

1. The possible existence of a β_3-adrenergic receptor (B_3-AR) in the human detrusor muscle was investigated by in vitro functional studies and analysis of mRNA expression. 2.Isoprenaline, noradrenaline and adrenaline each produced a concentration-dependent relaxation of the human detrusor. The rank order for their relaxing potencies was isoprenaline (pD_2 6.37 ± 0.07) ≥ noradrenaline (pD_2 6.07 ± 0.12) ≥ adrenaline (pD_2 5.88 ± 0.11).