Review article

摘要

Leukocyte-nedothelial cell adhesion has been implicated in the pathogenesis of a variety of diseases that affect different organ systems, Examples of such diseases include atherosclerosis, gastric ulcers, haemorrhagic shock, myocardial infarction, stroke, and malaria (Korthuis et al., 1994; Panes & Granger, 1998). The recognition that leukocytes must firmly adhere to vascular endothelial cells in order to mediate the organ dysfunction and tissue injury associated with these diseases has resulted in an intensive effort to define the factors that modulate this cell-cell interaction.