Electrophysiological examination of the effects of sustained flibanserin administration on serotonin receptors in rat brain

摘要

1. 5-HT_1A receptor agonists have proven to be effective antidepressant medications, however they suffer from a significant therapeutic lag before depressive symptoms abate. Flibanserin is a 5-HT_1A recepto agonist and 5-HT_2A receptor antagonist developed to possibly induce a more rapid onset of antidepressant action through its preferential postsynaptic 5-HT_1A receptor agonism.