Modulation of noradrenergic neuronal firing by selective serotonin Reuptake blockers

摘要

Using in vivo extracellular unitary recording, the effect of short term (2-day) and long-term (21-day) Administration of the selective 5-HT reuptake inhibitor (SSRI) paroxetine (10 mg kg~01 day~-1, s. c. Using osmoti minipumps) was examined on the spontaneous firing activity of locus coeruleus Noradrenergic neurons. Long-term but not short-term treatment significantly decreased firing Activity.