An in vitro electrophysiological study on the effects of phenytoin, lamotrigine and gabapentin on striatal neurons

摘要

1. We performed intracellular recordings from a rat corticostriatal slice preparation in order to compare the electrophysiological effects of the classical antiepileptic drug (AED) phenytoin (PHT) and the new AEDs lamotrgine (LTG) and gabapentin (GBP) on striatal neurons. 2. PHT, LTG and GBP affected neither the resting membrane potential nor the input resistance/ membrane conductance of the recorded cells. In contrast, these agents depressed in a dose-dependent and reversible manner the current-evoked repetitive firing discharge.