Beneficial effects of raxofelast (IRFI 016), A NEW HYDROPHILIC Vitamin E-Like antioxidant, in carrageenan-induced pleurisy

摘要

1. Peroxynitrite is a strong oxidant that results from reaction between NO and superoxide. It has been recently proposed that peroxynitrite plays a pathogenetic role in inflammatory processes. Here we have investigated the therapeutic efficacy of raxofelast, a new hydrophilic vitamin E-like antioxidant agent, in rats subjected to carrageenan-induced pleurisy. 2 In vivo treatment with raxofelast (5, 10, 20 mg kg~-1 intraperitoneally 5 min before carrageenan) prevented in a dose dependent manner carrageenan-induced pleural exudation and polymorpho- nuclear migration in rats subjected to carragenan-induced pleurisy.