Block by fluoxetine of volume-regulated anion channels

摘要

1. We have used the whole-cell patch clamp technique to study the effect of fluoxetine, a commonly used antidepressant drug, on the volume-regulated anion channel (VRAC) in calf pulmonary artery endothelial (CPAE) cells. We also examined its effects on other Cl~- channels, i.e. the Ca~2+ -activated Cl~- current (I_cl, Ca) and the cystic fibrosis transmembrane conductance regulator (CFTR) to assess The specificity of this compound for VRAC.