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Characterization of α_1-adrenoceptor subtypes mediating vasoconstriction in human umbilical vein

机译:介导人脐静脉血管收缩的α_1-肾上腺素受体亚型的特征

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摘要

1. The present study attempted to characterize pharmacologically the subtypes of α-adrenoceptors mediating contractions in human umbilical vein (HUV). 2. HUV rings were mounted in isolated organ baths and cumulative concentration-response curves were constructed for the α-adrenoceptor agonists phenylephrine and adrenaline. Adrenaline was more potent than phenylephrine (pD_2 = 7.29 and 6.04 respectively).
机译:1.本研究试图从药理学角度表征介导人脐静脉(HUV)收缩的α-肾上腺素受体亚型。 2.将HUV环安装在孤立的器官浴中,并绘制α-肾上腺素受体激动剂去氧肾上腺素和肾上腺素的累积浓度-响应曲线。肾上腺素比去氧肾上腺素更有效(分别为pD_2 = 7.29和6.04)。

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