Role of K~+ channels in A_2A adenosine receptor-mediated dilation the pressurized renal arcuate artery

摘要

1. Adenosine A_2A receptor-mediated renal vasodilation was investigated by measuring the lumenal diameter of pressurized renal arcuate arteries isolated from the rabbit. 2. The selective A_2A receptor agonist CGS21680 dilated the arteries with an EC_50 of 130 nM. The CGS21680-induced vasodilation was, on average, 34/100 less in endothelium-denuded arteries.